The fourth-generation Honda Integra (chassis code DC5), produced by Honda, was introduced in Japan on 13 April 2001, and produced from July 2001 until August 2006. It was introduced in North America on 2 July 2001[2] as the Acura RSX, the name a part of Acura's naming scheme changing the names of its models from recognizable names like "Integra" or "Legend" to alphabetical designations in order for buyers to build more recognition to the marque, and not the individual cars

In concordance with the introduction of the Integra's platform mate, the seventh-generation Civic being introduced in 2000, the Integra joined the Civic in abandoning Honda's traditional double wishbone suspension at both ends and adopted MacPherson struts in the front and trailing arm type suspension in the rear along with the new K-series engine supplanting the B-series.

The K-series engine features intelligent VTEC (or i-VTEC), which electronically adjusts valve lift, valve duration and valve timing, giving the 2.0 L engine a flatter torque curve relative to previous VTEC implementations which only adjusted valve lift and valve duration.

In Japan, the Integra was introduced in two versions, the iS (later renamed Type S in the 2004 refresh) and the Type R.

The iS/Type S (not to be confused with the RSX Type-S), featured the 2.0L DOHC i-VTEC 4-cylinder K20A3 engine with an output of 160 hp (120 kW) and mated to either a 5-speed automatic or a 5-speed manual transmission. The 2001-2003 iS was available with 15-inch steel wheels with covers, or optional 16-inch 5-spoke alloy wheels. The 2004-2006 Type S was equipped with 17-inch 5-spoke alloy wheels shared with the RSX Type-S. The JDM Type R had reduced weight, a 2.0L DOHC i-VTEC 4-cylinder K20A engine that output 217 hp (164 kw) (Japan-only; Oceania models use an engine similar to the RSX Type-S), 6-speed close-ratio manual transmission, as well as a helical limited-slip differential (LSD), stiffer springs and shocks, high intensity discharge (HID) bulbs paired with specially designed reflector headlights (different from all other RSX models), aluminum pedal set, 4-piston front Brembo brake calipers, 17-inch 5 double-spoke wheels on Bridgestone Potenza tires, Recaro suede seats/matching interior, leather wrapped MOMO steering wheel, body trim, front strut bar, and more. The Type R lacked many of the luxury features (like vanity mirrors or side airbags) found in the Type S, true to its racing heritage. The C package on the Type R added various accessories, such as a rear wiper, remote control, and folding mirrors.[6] The JDM iS had one interior color, Ebony, in its first year. After 2002, Titanium interiors became available for all exterior colors. The Type S had redesigned cloth and leather seats. The Type R had choices of black/blue/red interiors (including color matching Recaro seats), depending on exterior colors. The refreshed Type R had the option of either the high wing, or the trunk lip spoiler. Both the iS and Type S were available with sunroof, and navigation systems.[7] Additional interior and exterior accessories were available from Honda's Modulo line. Modulo accessories offered include interior trim (shift knobs, decals, etc.), foglights, aero kits (front/side/rear bumper enhancements), wing spoilers, alloy wheels, push button start, upgraded speakers, and navigation.

Japan's vehicle parts road compliance regulations means many tuning parts for the Integra can be purchased from Honda dealerships. For example, M&M Honda, a Honda dealer, manages their own brand of parts.Honda tuner Mugen sells their performance parts via Honda dealers as accessories.